The aim of the pre-vaccination blood and skin tests is to check for evidence of prior exposure to Coxiella burnetii;1,2
- The pre-vaccination blood test (or serological test) is performed to check for the presence of antibodies to Coxiella burnetii antigens (i.e. a positive test reveals the presence of antibodies to Coxiella burnetii antigens);1,2
- The pre-vaccination skin test – conducted using Q-VAX® Skin Test involves exposing the patient to a small amount of purified, killed Coxiella burnetii and then checking for evidence of an immune response, which would be indicative of prior exposure – and sensitisation – to Coxiella burnetii antigens.1,3
Using Q-VAX® Skin Test
The Q-VAX® Skin Test vial is packaged with a plastic tear away cap covering the vial septum; do not use if the tear away cap is damaged or missing.
1. ENSURE that a blood sample for the patient’s pre-vaccination blood test has been scheduled. The blood test can be done on the same day as the Q-VAX® Skin Test.3
NOTE: There is no need to conduct the Q-VAX® Skin Test if a patient’s blood test is positive; use of Q-VAX® Vaccine is contraindicated in this situation.1
2. PREPARE the Q-VAX® Skin Test solution1
- DILUTE 0.5 mL of Q-VAX® Skin Test solution in 14.5 mL of sodium chloride for injection (to a final volume of 15 mL), and MIX well.
NOTE: If required, diluted Q-VAX® Skin Test solution may be stored – at 4oC – for ≤ 6 hours prior to use.
3. INJECT the diluted Skin Test solution1
- Administer via intradermal injection only†
NOTE: DO NOT inject subcutaneously or intramuscularly.
Insert needle into volar surface of mid-forearm
Needle remains visible through the skin
Slowly inject 0.1 mL of diluted Q-VAX® Skin Test solution, until a bleb – or fluid-filled ‘blister’ – can be seen.‡1,2
† It is important to have some adrenaline on hand, for use in the unlikely event that the patient has an anaphylactic reaction to the diluted Skin Test solution.1
‡ If the diluted Q-VAX® Skin Test solution is inadvertently injected subcutaneously, and there’s therefore no ‘bleb’ formation, clinical experts usually recommend to simply repeat the procedure on the other arm.
Please note: Seqirus does not have recommendations regarding the repeated administration of Q-VAX® Skin Test solution. Seqirus does not endorse the use of Seqirus products, other than as described in the Australian Approved Product Information.1